By Mahmoud Ghannoum, Mahmoud A. Ghannoum, John R. Perfect MD, John R. Perfect
A concise one-stop-practical reference for a number of the physicians facing fungal infections, Antifungal remedy appeals to infectious illness physicians, transplant surgeons, dermatologists, and intensivists, in addition to easy scientists and pharmaceutical corporation researchers attracted to the nation of antifungal treatment. This booklet presents a complete, updated evaluate of the pertinent matters concerning antifungal remedy. Divided into 4 interrelated sections for a cohesive dialogue covers:
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Additional info for Antifungal Therapy
Skin lesions typically are papules with central necrosis involving the extremities, trunk, face, and mucocutaneous surfaces. Pulmonary presentation includes pleural effusion, interstitial pneumonia, and diffuse alveolar inﬁltrates. Lytic bone lesions or arthritis of the large joints and small joints of ﬁngers can occur. Anemia, leukopenia, and thrombocytopenia are often present (318,322–326). Most patients respond to treatment with itraconazole within one week, with complete resolution of cutaneous lesions after three weeks of treatment (326).
Immunosuppressed individuals may be newly exposed to P. jiroveci or experience reactivation of latent Pneumocystis infection, and disease may result from either recent acquisition or reactivation of long-standing, dormant organisms (458). Nosocomial transmission of PCP has been reported (448). PCP was the ﬁrst AIDS-deﬁning illness, and as the HIV epidemic has evolved, the epidemiology of PCP has also changed, especially after the advent of HAART (440,459). In patients with HIV/AIDS, PCP usually presents as a subacute onset of dyspnea, nonproductive cough, and occasionally low-grade fever.
Furfur or M. pachydermatis, has been reported in heart transplant, kidney transplant, and BMT recipients (418–421). The rash can present as an acneiform eruption or as folliculitis with a papular or papular-pustular appearance. Fever may precede the rash in BMT recipients (278,420,421). Malassezia, both M. furfur and M. pachydermatis, has been implicated in fungemia in adults, children, and infants receiving intravenous lipids or with prolonged catheterization (410,412,413,422,423). The central venous catheter is most often considered the portal of entry though other sites, such as upper respiratory tract, lung, and urine, may be colonized or infected.
Antifungal Therapy by Mahmoud Ghannoum, Mahmoud A. Ghannoum, John R. Perfect MD, John R. Perfect